Helicobacter pylori inhibits GKN1 expression via the CagA/p-ERK/AUF1 pathway.

Yanlei GuoTing ZhangYanyan ShiJing ZhangMingyu LiFengmin LuJing ZhangXiangmei ChenShigang Ding

Published in: Helicobacter (2019)

Our data demonstrated that H. pylori infection downregulated GKN1 expression via the CagA/p-ERK/AUF1 pathway. AUF1 promoted gastric cancer at least partly through downregulating GKN1, which presented a novel potential target for the treatment of gastric cancer.

Keyphrases

helicobacter pylori
poor prognosis
helicobacter pylori infection
signaling pathway
cell proliferation
pi k akt
binding protein
long non coding rna
combination therapy
artificial intelligence
deep learning
smoking cessation