A Multi-Omics Approach to Defining Target Organ Injury in Youth with Primary Hypertension.
Kalyani AnanthamohanTammy M BradyMohammed ArifStephen DanielsBonita FalknerMichael FergusonJoseph T FlynnCoral D HanevoldStephen R HooperJulie IngelfingerMarc LandeLisa J MartinKevin E MeyersMark MitsnefesBernard RosnerJoshua A SamuelsGina KuffelMichael J ZillioxRichard C BeckerElaine M UrbinaSakthivel SadayappanPublished in: bioRxiv : the preprint server for biology (2024)
The findings are compatible with a novel blood pressure-associated mechanism that may occur through impaired angiogenesis and extracellular matrix degradation through dysregulation of Vasohibin-1 and Hyaluronidase1 was identified as a possible mediator of CV-TOI in youth with high-BP and suggests strategies for ameliorating TOI in adult-onset primary hypertension.