The GLP-1 receptor is expressed in vivo by human metastatic prostate cancer.
Mark Simon SteinVictor KalffScott G WilliamsDeclan G MurphyPeter G ColmanMichael S HofmanPublished in: Endocrine oncology (Bristol, England) (2024)
GLP-1R expression by human mCPRC, detecting PET/CT lesions avid for both PSMA and exendin, in one of four participants. GLP-1R expression may thus occur even in advanced-stage prostate cancer. Our data contribute to growing evidence supporting the testing of GLP-1 receptor agonists for therapeutic benefit in prostate cancer.