Elevated Levels of Follicular Fatty Acids Induce Ovarian Inflammation via ERK1/2 and Inflammasome Activation in PCOS.

Yuchen LaiZhenhong YeLiangshan MuYurong ZhangXiaoyu LongChunmei ZhangRong LiYue Zhao Jie Qiao

Published in: The Journal of clinical endocrinology and metabolism (2022)

Fatty acid metabolism was significantly altered in the follicular niche of PCOS patients. Elevated levels of fatty acids could induce ovarian inflammation both at the transcriptional level and in posttranslational processing.

Keyphrases

fatty acid
oxidative stress
end stage renal disease
polycystic ovary syndrome
ejection fraction
newly diagnosed
chronic kidney disease
signaling pathway
gene expression
transcription factor
type diabetes
skeletal muscle
metabolic syndrome
pi k akt
heat shock protein