Neurofilament light oligomers in neurodegenerative diseases: quantification by homogeneous immunoassay in cerebrospinal fluid.
Francisco J MedaKathryn KnowlesImogen Joanna SwiftAitana Sogorb-EsteveJonathan Daniel RohrerAnna DittrichIngmar SkoogSilke KernBruno BeckerKaj BlennowUlf AndreassonHlin KvartsbergHenrik ZetterbergPublished in: BMJ neurology open (2023)
The homogeneous ELISA and SEC data suggest that most of the NfL in both the calibrator and human CSF is present as a dimer. In CSF, the dimer appears to be truncated. Further studies are needed to determine its precise molecular composition.