Acute Symptoms of Mild to Moderate COVID-19 Are Highly Heterogeneous Across Individuals and Over Time.
Thomas L RodebaughMadelyn R FrumkinAngela M ReiersenEric J LenzeMichael S AvidanJ Philip MillerJay F PiccirilloCharles F ZorumskiCaline MattarPublished in: Open forum infectious diseases (2021)
The course of symptoms during the initial weeks of COVID-19 is highly heterogeneous and is neither predictable nor easily characterized using typical survey methods. This has implications for clinical care and early-treatment clinical trials. Additional research is needed to determine whether the decelerating improvement pattern seen in our data is related to the phenomenon of patients reporting long-term symptoms and whether higher symptoms of diarrhea in early illness presages deterioration.
Keyphrases
- coronavirus disease
- clinical trial
- sars cov
- sleep quality
- end stage renal disease
- healthcare
- ejection fraction
- chronic kidney disease
- newly diagnosed
- palliative care
- liver failure
- prognostic factors
- randomized controlled trial
- depressive symptoms
- quality improvement
- big data
- deep learning
- hepatitis b virus
- machine learning
- drug induced
- respiratory failure
- pain management
- clostridium difficile
- irritable bowel syndrome
- gestational age
- patient reported
- affordable care act