Correlations between pathogenic variants in DNA repair genes and anticancer treatment efficacy in stage IV non-small cell lung cancer: A large real-world cohort and review of the literature.
Itamar AverbuchRoi TschernichovskyOded IchtDaniel A GoldsteinRaz MutaiElizabeth DudnikOfer RotemNir PeledAaron M AllenSmadar Laufer-GevaYael GoldbergAlona ZerPublished in: Thoracic cancer (2023)
Our retrospective data suggest that in patients with stage 4 NSCLC, pathogenic variants in DDR pathway genes may be associated with higher efficacy of radiotherapy and immune checkpoint inhibitors (ICIs). This should be further explored prospectively.
Keyphrases
- dna repair
- dna damage
- copy number
- genome wide
- small cell lung cancer
- early stage
- bioinformatics analysis
- dna damage response
- cross sectional
- radiation therapy
- electronic health record
- genome wide identification
- advanced non small cell lung cancer
- deep learning
- genome wide analysis
- brain metastases
- combination therapy
- machine learning
- transcription factor
- gene expression
- epidermal growth factor receptor
- smoking cessation