Is Osteopontin a Friend or Foe of Cell Apoptosis in Inflammatory Gastrointestinal and Liver Diseases?
Tomoya IidaKohei WagatsumaDaisuke HirayamaHiroshi NakasePublished in: International journal of molecular sciences (2017)
Osteopontin (OPN) is involved in a variety of biological processes, including bone remodeling, innate immunity, acute and chronic inflammation, and cancer. The expression of OPN occurs in various tissues and cells, including intestinal epithelial cells and immune cells such as macrophages, dendritic cells, and T lymphocytes. OPN plays an important role in the efficient development of T helper 1 immune responses and cell survival by inhibiting apoptosis. The association of OPN with apoptosis has been investigated. In this review, we described the role of OPN in inflammatory gastrointestinal and liver diseases, focusing on the association of OPN with apoptosis. OPN changes its association with apoptosis depending on the type of disease and the phase of disease activity, acting as a promoter or a suppressor of inflammation and inflammatory carcinogenesis. It is essential that the roles of OPN in those diseases are elucidated, and treatments based on its mechanism are developed.
Keyphrases
- oxidative stress
- cell cycle arrest
- induced apoptosis
- dendritic cells
- endoplasmic reticulum stress
- cell death
- disease activity
- immune response
- rheumatoid arthritis
- pi k akt
- systemic lupus erythematosus
- gene expression
- regulatory t cells
- ankylosing spondylitis
- bone mineral density
- drug induced
- signaling pathway
- liver failure
- rheumatoid arthritis patients
- young adults
- papillary thyroid
- body composition
- postmenopausal women
- long non coding rna
- childhood cancer
- bone loss