Case of type 2 diabetes possibly caused by excessive accumulation of visceral fat in a child born small-for-gestational age.
Remi KuwabaraTatsuhiko UrakamiKei YoshidaIchiro MoriokaPublished in: Journal of diabetes investigation (2020)
We encountered a 12-year-old boy with type 2 diabetes who was born small-for-gestational age. We described his clinical characteristics and a possible etiological factor for development of hyperglycemia. He developed well with sufficient nutrition and progressed to being overweight at 6 years-of-age as a result of a high-calorie, high-protein intake diet. He showed a diabetic pattern with a normal insulin response on an oral glucose tolerance test carried out with the urine glucose screening program at schools. He showed a large total fat area of 239.4 cm2 ; in particular, his visceral fat area was 103.0 cm2 with a high ratio of visceral fat area to subcutaneous fat area (0.76). The present case might show that insulin resistance, possibly as a result of accumulation of a great amount of visceral fat, might be attributed to the pathogenesis of type 2 diabetes in children born small-for-gestational age.
Keyphrases
- gestational age
- insulin resistance
- adipose tissue
- birth weight
- type diabetes
- preterm birth
- fatty acid
- high fat diet
- physical activity
- weight loss
- weight gain
- glycemic control
- metabolic syndrome
- cardiovascular disease
- young adults
- mental health
- preterm infants
- blood pressure
- polycystic ovary syndrome
- high fat diet induced
- quality improvement
- small molecule