An Antidepressant Drug Increased TRAIL Receptor-2 Expression and Sensitized Lung Cancer Cells to TRAIL-induced Apoptosis.

K M A ZinnahJae-Won SeolByung-Yong ParkSang-Youel ParkAli Newaz Munna

Published in: Anti-cancer agents in medicinal chemistry (2023)

Our findings revealed the potential of desipramine to induce TRAIL-mediated cell death by autophagy impairment. This discovery suggests its therapeutic potential for inducing TRAIL-mediated cell death by increasing the expression of death receptors, which is caused by impairing autophagy.

Keyphrases

cell death
induced apoptosis
endoplasmic reticulum stress
signaling pathway
cell cycle arrest
oxidative stress
poor prognosis
small molecule
high throughput
single cell
emergency department
risk assessment
human health
climate change