YY1 lactylation in microglia promotes angiogenesis through transcription activation-mediated upregulation of FGF2.

Xiaotang WangWei FanNa LiYan MaMudi YaoGuoqing WangSiyuan HeWanqian LiJun TanQi LuShengping Hou

Published in: Genome biology (2023)

Our results suggest that YY1 lactylation in microglia plays an important role in retinal neovascularization by upregulating FGF2 expression. Targeting the lactate/p300/YY1 lactylation/FGF2 axis may provide new therapeutic targets for proliferative retinopathies.

Keyphrases

poor prognosis
diabetic retinopathy
inflammatory response
vascular endothelial growth factor
neuropathic pain
endothelial cells
optical coherence tomography
cell proliferation
cancer therapy
transcription factor
optic nerve
spinal cord
wound healing