Reverse Transcriptase Inhibition Disrupts Repeat Element Life Cycle in Colorectal Cancer.
Mihir RajurkarAparna R ParikhAlexander SolovyovEunae YouAnupriya S KulkarniChong ChuKatherine H XuChristopher JaicksMartin S TaylorConnie WuKatherine A AlexanderCharly R GoodAnnamaria SzabolcsStefanie GerstbergerAntuan V TranNova XuRichard Y EbrightEmily E Van SeventerKevin D VoEric C TaiChenyue LuJasmin Joseph-ChazanMichael J RaabeLinda T NiemanNiyati DesaiKshitij S AroraMatteo LigorioVishal ThaparLimor CohenPadric M GardenYasmeen SenussiHui ZhengJill N AllenLawrence S BlaszkowskyJeffrey W ClarkLipika GoyalJennifer Y WoDavid P RyanRyan B CorcoranVikram DeshpandeMiguel N RiveraMartin J AryeeTheodore S HongShelley L BergerDavid R WaltKathleen H BurnsPeter J ParkBenjamin D GreenbaumDavid Tsai TingPublished in: Cancer discovery (2022)
Colorectal cancers express abundant repeat elements that have a viral-like life cycle that can be therapeutically targeted with nucleoside reverse transcriptase inhibitors (NRTI) commonly used for viral diseases. NRTIs induce DNA damage and interferon response that provide a new anticancer therapeutic strategy. This article is highlighted in the In This Issue feature, p. 1397.