Leptin Induces MMP-1 Expression Through the RhoA/ERK1/2/NF-κB Axis in Human Intervertebral Disc Cartilage Endplate-Derived Stem Cells.
Kuo-Feng HuaLan-Hui LiHsin-Chiao YuWei-Ting WongHsien-Ta HsuPublished in: Journal of inflammation research (2023)
These results indicated that leptin induced MMP-1 expression in SV40 cells through the RhoA/ERK1/2/NF-κB axis. This study provided the pathogenic role of leptin and suggested the potential therapeutic target for IVD degeneration.
Keyphrases
- signaling pathway
- pi k akt
- induced apoptosis
- stem cells
- poor prognosis
- cell cycle arrest
- endothelial cells
- lps induced
- cell proliferation
- oxidative stress
- high glucose
- binding protein
- nuclear factor
- cell migration
- long non coding rna
- immune response
- risk assessment
- cell therapy
- extracellular matrix
- mesenchymal stem cells
- human health
- toll like receptor