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ARID1A loss activates MAPK signaling via DUSP4 downregulation.

Jayaprakash MandalZheng-Cheng YuIe-Ming ShihTian-Li Wang
Published in: Journal of biomedical science (2023)
Our findings suggest that ARID1A protein transcriptionally modulates DUSP4 expression by remodeling chromatin, subsequently inactivating the MAPK pathway, leading to tumor suppression. The ARID1A-DUSP4-MAPK axis may be further considered for developing targeted therapies against ARID1A-mutated cancers.
Keyphrases
  • signaling pathway
  • pi k akt
  • oxidative stress
  • poor prognosis
  • gene expression
  • dna damage
  • cell proliferation
  • binding protein
  • transcription factor
  • amino acid
  • young adults
  • dna methylation
  • long non coding rna