Management guidelines for paediatric patients receiving chimeric antigen receptor T cell therapy.
Kris M MahadeoSajad Jawad KhazalHisham Abdel-AzimJulie C FitzgeraldAgne TaraseviciuteCatherine M BollardPriti TewariChristine DuncanChani TraubeDavid McCallMarie E SteinerIra M CheifetzLeslie E LehmannRodrigo MejiaJohn M SlopisRajinder BajwaPartow KebriaeiPaul L MartinJerelyn MoffetJennifer McArthurDemetrios PetropoulosJoan O'Hanlon CurrySarah FeatherstonJessica FoglesongBasirat ShoberuAlison GulbisMaria E MirelesLisa HafemeisterCathy NguyenNeena KapoorKatayoun RezvaniSattva S NeelapuElizabeth J Shpallnull nullPublished in: Nature reviews. Clinical oncology (2019)
In 2017, an autologous chimeric antigen receptor (CAR) T cell therapy indicated for children and young adults with relapsed and/or refractory CD19+ acute lymphoblastic leukaemia became the first gene therapy to be approved in the USA. This innovative form of cellular immunotherapy has been associated with remarkable response rates but is also associated with unique and often severe toxicities, which can lead to rapid cardiorespiratory and/or neurological deterioration. Multidisciplinary medical vigilance and the requisite health-care infrastructure are imperative to ensuring optimal patient outcomes, especially as these therapies transition from research protocols to standard care. Herein, authors representing the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network Hematopoietic Stem Cell Transplantation (HSCT) Subgroup and the MD Anderson Cancer Center CAR T Cell Therapy-Associated Toxicity (CARTOX) Program have collaborated to provide comprehensive consensus guidelines on the care of children receiving CAR T cell therapy.
Keyphrases
- cell therapy
- healthcare
- quality improvement
- gene therapy
- stem cells
- mesenchymal stem cells
- clinical practice
- acute myeloid leukemia
- young adults
- intensive care unit
- palliative care
- affordable care act
- acute lymphoblastic leukemia
- liver failure
- emergency department
- papillary thyroid
- childhood cancer
- body composition
- pain management
- early onset
- high intensity
- randomized controlled trial
- multiple myeloma
- squamous cell
- diffuse large b cell lymphoma
- hematopoietic stem cell
- molecular dynamics
- hepatitis b virus
- chronic pain
- middle aged
- phase iii
- lps induced
- septic shock
- open label
- health information
- extracorporeal membrane oxygenation
- health insurance