Genome-Wide Meta-Analysis Identifies Three Novel Susceptibility Loci and Reveals Ethnic Heterogeneity of Genetic Susceptibility for IgA Nephropathy.

Ming LiLing WangDian-Chun ShiJia-Nee FooZhong ZhongChiea-Chuen KhorChiara LanzaniLorena CitterioErika SalviPei-Ran YinJin-Xin BeiLi WangYun-Hua LiaoJian ChenQin-Kai ChenGang XuGeng-Ru JiangJian-Xin WanMeng-Hua ChenNan ChenHong ZhangYi-Xin ZengZhi-Hong LiuJian-Jun LiuXue-Qing Yu

Published in: Journal of the American Society of Nephrology : JASN (2020)

A meta-analysis of GWAS data revealed three novel genetic risk loci for IgAN, and three HLA polymorphisms and two SNPs within the MHC region, and demonstrated the genetic heterogeneity of seven loci out of 24 confirmed risk SNPs. These variants may explain susceptibility differences between Chinese and European populations.

Keyphrases

genome wide
copy number
dna methylation
single cell
systematic review
gene expression
randomized controlled trial
meta analyses
electronic health record
machine learning
case control
data analysis