Afriplex GRTTM extract attenuates hepatic steatosis in an in vitro model of NAFLD.

Kwazikwakhe B Gabuza Thendo I MabudaOelfah PatelNoxolo KhuboniRuzayda van AardeSylvia RiedelNonhlakanipho F SangweniShantal WindvogelRabia JohnsonChristo John Frederick Muller

Published in: PloS one (2024)

Afriplex GRTTM reduced hepatic steatosis in oleic acid induced C3A liver cells by modulating SREBF1, ChREBP and IRS-1 gene expression. The extract may also play a role in alleviating inflammation by reducing TNF-α expression, suggesting that additional experiments are required for its development as a suitable therapeutic option against NAFLD. Importantly, further research is needed to explore its antioxidant role in this model.

Keyphrases

oxidative stress
gene expression
induced apoptosis
anti inflammatory
poor prognosis
dna methylation
cell cycle arrest
long non coding rna
endoplasmic reticulum stress