Microarray analysis identifies defects in regenerative and immune response pathways in COPD airway basal cells.
Fanny PineauGabriella ShumyatskyNicole OwuorNisha NalamalaSudhir KotnalaSudhir BollaNathaniel MarchettiSteven KelsenGerard J CrinerUmadevi S SajjanPublished in: ERJ open research (2020)
Defect in gene signatures involved in tissue development and epithelial differentiation were implicated in COPD basal cells. One of the tissue developmental genes, HOXB2, is substantially reduced in bronchial epithelium of COPD patients. Since HOXB2 contributes to airway epithelial cell polarisation, we speculate that reduced expression of HOXB2 in COPD may contribute to abnormal airway epithelial regeneration in COPD.
Keyphrases
- chronic obstructive pulmonary disease
- lung function
- induced apoptosis
- genome wide
- stem cells
- immune response
- cell cycle arrest
- end stage renal disease
- newly diagnosed
- ejection fraction
- chronic kidney disease
- poor prognosis
- cell death
- dna methylation
- cystic fibrosis
- copy number
- air pollution
- mesenchymal stem cells
- endoplasmic reticulum stress
- gene expression
- genome wide identification
- bone marrow
- inflammatory response
- long non coding rna