Cystic fibrosis newborn screening: the importance of bloodspot sample quality.
I J M DoullChristopher William CourseRuth E HanksKevin W SouthernJulian T FortonLena P ThiaStuart J MoatPublished in: Archives of disease in childhood (2020)
The majority of false negatives had a low bloodspot IRT, and this was associated with poor quality DBS. The optimal means to improve the sensitivity of our CF NBS programme would be to improve DBS sample quality.