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Lactobacillus acidophilus supernatant alleviates osteoporosis by upregulating colonic SERT expression.

Jianhua ZhaiSiyuan SunJing ChengJing WangGe JinXiuxiu XuXiaotong LiuJingwen ZhaoChen ChenWeilong ZhongBang-Mao Wang
Published in: Future microbiology (2023)
Aims: To investigate the involvement of serotonin transporter (SERT) in colonic epithelial cells in the anti-osteoporosis role of Lactobacillus acidophilus (LA) supernatant (LAS). Methods: The abundance of fecal LA and bone mineral density (BMD) in patients with osteoporosis (OP) or severe osteoporosis were assessed. The protective role of LA in osteoporosis and the expression of SERT and relative signaling were evaluated. Results: Abundance of fecal LA was decreased in patients with severe OP and was positively correlated with BMD. Supplementing LAS to mice alleviated senile osteoporosis. In vitro , NOD2/RIP2/NF-κB signaling was inhibited by LAS due to increased SERT expression. Conclusion: LAS alleviates OP in mice by producing protective metabolites and upregulating SERT expression and represents a promising therapeutic agent.
Keyphrases
  • bone mineral density
  • postmenopausal women
  • poor prognosis
  • body composition
  • early onset
  • ms ms
  • cell proliferation
  • immune response
  • microbial community
  • skeletal muscle
  • ulcerative colitis
  • high fat diet induced