Lymphocyte activation gene-3 (LAG3) mRNA and protein expression on tumour infiltrating lymphocytes (TILs) in oesophageal adenocarcinoma.

Florian GebauerMax KrämerChristiane BrunsHans A SchlößerMartin ThelenPhilipp LohneisWolfgang SchröderThomas ZanderHakan AlakusReinhard BuettnerHeike LoeserAlexander Quaas

Published in: Journal of cancer research and clinical oncology (2020)

This is the first description of LAG3 expression on TILs in EAC, underscoring the importance of immunomodulation in EAC. Our data suggest an impact of LAG3 in a relevant subset of EAC. Therapeutic studies investigating the efficacy of LAG3 inhibition in EAC will also provide predictive evidence and relevance of the immunohistochemical determination of LAG3 expression.

Keyphrases

poor prognosis
binding protein
peripheral blood
squamous cell carcinoma
genome wide
gene expression
long non coding rna
copy number
mass spectrometry
big data
case control
solid phase extraction