Small-molecule inhibition of prostaglandin E receptor 2 impairs cyclooxygenase-associated malignant glioma growth.

Jiange QiuQianqian LiKatherine A BellXue YaoYifeng DuErik ZhangJane J YuYing YuZhi ShiJianxiong Jiang

Published in: British journal of pharmacology (2019)

Taken together, our results suggest that PGE2 signalling via the EP2 receptor increases the malignant potential of human glioma cells and might represent a novel therapeutic target for GBM.

Keyphrases

small molecule
endothelial cells
protein protein
pluripotent stem cells
human health