Systematic review of the impact of cannabinoids on neurobehavioral outcomes in preclinical models of traumatic and nontraumatic spinal cord injury.
Faheem I BhattiOliver D MowforthMax B ButlerAniqah I BhattiSylva AdeekoMelika AkhbariRory DilworthBen GrodzinskiTemidayo OsunronbiLuke OttewellJye Quan TehSophie RobinsonGayathri SureshUnaiza WaheedBenn WalkerIsla KhunLara SmithRichard D BartlettBenjamin M DaviesMark Reinhard KotterPublished in: Spinal cord (2021)
Modulation of the endo-cannabinoid system has demonstrated significant improvement in both pain and locomotor function in pre-clinical SCI models; however, the risk of bias is unclear in all studies. These results may help to contextualise future translational clinical trials investigating whether cannabinoids can improve pain and locomotor function in SCI patients.
Keyphrases
- spinal cord injury
- neuropathic pain
- systematic review
- spinal cord
- clinical trial
- chronic pain
- end stage renal disease
- pain management
- ejection fraction
- newly diagnosed
- peritoneal dialysis
- meta analyses
- randomized controlled trial
- patient reported outcomes
- cell therapy
- mesenchymal stem cells
- type diabetes
- patient reported
- open label
- glycemic control
- weight loss