Oxycodone or Higher Dose of Levodopa for the Treatment of Parkinsonian Central Pain: OXYDOPA Trial.

Christine Brefel-CourbonEstelle HarrochAna-Raquel MarquesDavid DevosClaire ThalamasVanessa RousseauFabienne Ory-MagneMargherita FabbriDavid MaltêteTiphaine RouaudSophie DrapierMelissa TirStephane ThoboisHayet SalhiJean-Christophe CorvolGiovanni CastelnovoOuhaid Lagha-BoukbizaFréderique FluchèreSolene FrismandSolene AnsquerAgnes SommetOlivier Rascol

Published in: Movement disorders : official journal of the Movement Disorder Society (2024)

The present trial failed to demonstrate the superiority of oxycodone-PR or a higher dose of levodopa in patients with PCP, while oxycodone-PR was poorly tolerated. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.

Keyphrases

parkinson disease
phase iii
study protocol
deep brain stimulation
phase ii
clinical trial
chronic pain
pain management
open label
neuropathic pain
randomized controlled trial
systematic review
double blind
postoperative pain