The Oxford Classic Links Epithelial-to-Mesenchymal Transition to Immunosuppression in Poor Prognosis Ovarian Cancers.

Zhiyuan HuPaula CunneaZhe ZhongHaonan LuOloruntoba I OsagieLeticia CampoMara ArtibaniKatherine NixonJennifer PloskiLaura Santana GonzalezAbdulkhaliq AlsaadiNina WietekStephen DamatoSunanda DharSarah P BlagdenChristopher YauJoanna HesterAshwag AlbukhariEric O AboagyeChristina FotopoulouAhmed Ahmed

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

The OxC-defined EMT-high SOCs carry particularly poor prognosis independent of established clinical parameters. These tumors are associated with high frequency of immunosuppressive macrophages, suggesting a potential therapeutic target to improve clinical outcome.

Keyphrases

poor prognosis
high frequency
transcranial magnetic stimulation
long non coding rna
epithelial mesenchymal transition
human health
signaling pathway