Contribution of FoxP3+ Tfr cells to overall human blood CXCR5+ T cells.
V R FonsecaLuís GraçaPublished in: Clinical and experimental immunology (2019)
The identification that T follicular helper (Tfh) cells is critical for the emergence of germinal centre responses prompted the study of CXCR5-expressing CD4+ T cell subsets in autoimmunity. However, circulating CXCR5-expressing T cells are heterogeneous by containing Forkhead box protein 3 (FoxP3)+ T follicular regulatory (Tfr) cells in addition to bona fide Tfh cells. Such heterogeneity may hamper the analysis of the contribution of specific follicular T cell subsets for autoimmune pathogenesis. Therefore, separate assessment of Tfh and Tfr populations offer greater opportunities for stratification of autoimmune patients, such as Sjögren's syndrome patients.
Keyphrases
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- regulatory t cells
- endothelial cells
- transcription factor
- peritoneal dialysis
- signaling pathway
- cell death
- oxidative stress
- small molecule
- rheumatoid arthritis
- systemic lupus erythematosus
- binding protein
- amino acid
- pluripotent stem cells
- protein protein
- genetic diversity