Synthetic amyloid beta does not induce a robust transcriptional response in innate immune cell culture systems.

I Y QuirogaA E CruikshankM L BondK S M ReedB A EvangelistaJ H TsengJ V RagusaR B MeekerH WonS CohenT J CohenDouglas H Phanstiel

Published in: Journal of neuroinflammation (2022)

These results suggest that synthetic Aβ treatment of innate immune cell cultures does not recapitulate transcriptional profiles observed in microglia from AD brains. In contrast, treating IMGL with LPS and INFγ induces transcriptional changes similar to those observed in microglia detected in AD brains.

Keyphrases

innate immune
inflammatory response
gene expression
transcription factor
heat shock
magnetic resonance
single cell
cell therapy
magnetic resonance imaging
anti inflammatory
mesenchymal stem cells
bone marrow
spinal cord
spinal cord injury