Systemic administration of β-glucan induces immune training in microglia.
Yang HengXiaoming ZhangMalte BorggreweHilmar R J van WeeringMaaike L BrummerTjalling W NijboerLeo A B JoostenMihai G NeteaErik W G M BoddekeJon D LamanBart J L EggenPublished in: Journal of neuroinflammation (2021)
Our results demonstrate that preconditioning with BG and LPS both induced immune training of microglia at two days after the first challenge. However, with an interval of 7 days between the first and second challenge, LPS-preconditioning resulted in immune tolerance in microglia.