Self-organized insulin-producing β-cells differentiated from human omentum-derived stem cells and their in vivo therapeutic potential.
Ji Hoon JeongKi Nam ParkJoo Hyun KimKyungMu NohSung Sik HurYunhye KimMoonju HongJun Chul ChungJae Hong ParkJongsoon LeeYoung-Ik SonJu Hun LeeSang-Heon KimYongsung HwangPublished in: Biomaterials research (2023)
Our findings suggest that the FGF2-immobilized matrix can support initial cell adhesion, maturation, and glucose-stimulated insulin secretion within the host microenvironment. Such a cell culture platform can offer novel strategies to obtain functional pancreatic β-cells from patient-specific cell sources, ultimately enabling better treatment for diabetes mellitus.
Keyphrases
- stem cells
- cell adhesion
- induced apoptosis
- cell therapy
- endothelial cells
- type diabetes
- cell cycle arrest
- glycemic control
- single cell
- high throughput
- drinking water
- blood glucose
- induced pluripotent stem cells
- endoplasmic reticulum stress
- cell death
- combination therapy
- adipose tissue
- pluripotent stem cells
- oxidative stress
- insulin resistance
- signaling pathway
- replacement therapy