Genetic variation, intrauterine growth, and adverse pregnancy conditions predict leptin gene DNA methylation in blood at birth and 12 months of age.
Toby MansellAnne-Louise PonsonbyFiona CollierDavid BurgnerPeter VuillerminKatherine LangeJoanne RyanRichard Safferynull nullPublished in: International journal of obesity (2005) (2019)
Infant sex, weight, genetic variation, and exposure to pre-eclampsia and gestational diabetes, are associated with LEP methylation in cord blood. Infant adiposity at birth predicts 12-month blood LEP methylation in a genotype-dependent manner. These findings are consistent with genetics and anthropometry driving altered LEP epigenetic profile and expression in infancy. Further work is required to confirm this and to determine the long-term impact of altered LEP methylation on health.
Keyphrases
- dna methylation
- genome wide
- cord blood
- pregnancy outcomes
- weight gain
- gene expression
- copy number
- gestational age
- poor prognosis
- public health
- healthcare
- mental health
- preterm birth
- body mass index
- insulin resistance
- weight loss
- physical activity
- pregnant women
- health promotion
- transcription factor
- social media
- risk assessment
- long non coding rna
- skeletal muscle
- adverse drug