The FBXW7-NOTCH interactome: A ubiquitin proteasomal system-induced crosstalk modulating oncogenic transformation in human tissues.

Rohan Kar Saurabh Kumar Jha Shreesh Kumar Ojha Ankur SharmaSunny DholpuriaVenkata Sita Rama RajuParteek PrasherDinesh Kumar ChellappanGaurav GuptaSachin Kumar SinghKeshav Raj PaudelPhilip M HansbroSandeep Kumar SinghJanne RuokolainenKavindra Kumar Kesari Kamal Dua Niraj Kumar Jha

Published in: Cancer reports (Hoboken, N.J.) (2021)

The review concludes by positioning FBXW7 as an effective diagnostic marker in tumors and by listing out recent advancements made in cancer therapeutics in identifying protocols targeting the FBXW7-NOTCH aberrations in tumors.

Keyphrases

endothelial cells
high glucose
small molecule
papillary thyroid
cell proliferation
diabetic rats
gene expression
squamous cell
induced pluripotent stem cells
copy number
signaling pathway
transcription factor
pluripotent stem cells
cancer therapy
dna methylation
lymph node metastasis