Ophiobolins from the Mangrove Fungus Aspergillus ustus.
Tonghan ZhuZhenyu LuJie FanLiping WangGuoliang ZhuYi WangXia LiKui HongPawinee PiyachaturawatArthit ChairoungduaWeiming ZhuPublished in: Journal of natural products (2017)
Seven new ophiobolins (1-5, 12, and 14) along with the 11 known analogues (6-11, 13, 15-18) were isolated from the ethyl acetate extracts of the liquid and solid cultures of the mangrove fungus Aspergillus ustus 094102. The structures including the absolute configurations of the seven new compounds were elucidated by spectroscopic analysis, chemical methods, and quantum ECD calculations. Compounds 4-8 and 11-15 showed cytotoxicities against the G3K, MCF-7, MD-MBA-231, MCF/Adr, A549, and HL-60 human cancer cell lines with the IC50 values ranging from 0.6 to 9.5 μM.
Keyphrases
- molecular dynamics
- breast cancer cells
- molecular docking
- endothelial cells
- papillary thyroid
- ionic liquid
- density functional theory
- cell wall
- high resolution
- squamous cell
- induced pluripotent stem cells
- squamous cell carcinoma
- adverse drug
- pluripotent stem cells
- emergency department
- mass spectrometry
- lymph node metastasis