Proton pump inhibitors and risk of all-cause and cause-specific mortality: A cohort study.

Jeremy Philip BrownJohn R TazareElizabeth WilliamsonKathryn E MansfieldStephen J EvansLaurie A TomlinsonKrishnan BhaskaranLiam SmeethKevin WingIan J Douglas

Published in: British journal of clinical pharmacology (2021)

PPI prescription was strongly associated with all-cause and cause-specific mortality. However, the change in hazard ratios (a) by increasing adjustment and (b) between comparator groups indicates that residual confounding is likely to explain the association between poor health outcomes and PPI use, and fully accounting for this using observational data may not be possible.

Keyphrases

cardiovascular events
protein protein
risk factors
type diabetes
cross sectional
big data
cardiovascular disease
small molecule
deep learning