Red beetroot extract mitigates chlorpyrifos-induced reprotoxicity associated with oxidative stress, inflammation, and apoptosis in rats.
Gadah AlBasherTarfa AlbrahimNouf AlsultanSaleh AlfarajMada S AlharthiRami B KassabAhmed E Abdel MoneimPublished in: Environmental science and pollution research international (2019)
The goal of our investigation is to evaluate the potential protective efficacy of red beetroot extract (RBR) against testicular toxicity produced by CPF in rats. CPF exposure decreased the weight of testis and the levels of luteinizing hormone, follicle stimulating hormone and testosterone. CPF impaired also the oxidative status in favor of pro-oxidant molecules in the testicular tissue. Additionally, CPF stimulated the production of pro-inflammatory cytokines and their gene expression. Concomitantly, an apoptotic cascade has been observed upon CPF intoxication. However, RBR administration protected the testis tissue through modulating the hormonal level, inhibiting the oxidative damage, inflammation and the apoptotic responses following CPF intoxication. The obtained data recommend the use of RBR to prevent CPF-induced testicular damage via antioxidant, anti-inflammatory, and anti-apoptotic pathways.
Keyphrases
- anti inflammatory
- oxidative stress
- genome editing
- diabetic rats
- crispr cas
- gene expression
- germ cell
- cell death
- dna damage
- ischemia reperfusion injury
- induced apoptosis
- high glucose
- signaling pathway
- physical activity
- body mass index
- dna methylation
- metabolic syndrome
- drug induced
- type diabetes
- weight loss
- endoplasmic reticulum stress
- radiation induced
- insulin resistance
- electronic health record
- climate change
- replacement therapy
- body weight
- big data
- skeletal muscle
- weight gain