Accelerated brain aging towards transcriptional inversion in a zebrafish model of the K115fs mutation of human PSEN2.

Nhi Hin Morgan NewmanJan KaslinAlon M DouekAmanda LumsdenSeyed Hani Moussavi NikYang DongXin-Fu ZhouNoralyn B Mañucat-TanAlastair LudingtonDavid L AdelsonStephen PedersonMichael Lardelli

Published in: PloS one (2020)

Our results suggest that forced expression of a PS2V-like isoform contributes to immune and stress responses favouring AD pathogenesis. This highlights the value of our zebrafish genetic model for exploring molecular mechanisms involved in AD pathogenesis.

Keyphrases

endothelial cells
poor prognosis
gene expression
early onset
white matter
genome wide
resting state
multiple sclerosis
induced pluripotent stem cells
computed tomography
binding protein
blood brain barrier
functional connectivity
brain injury
cerebral ischemia
heat stress