STAT3 activation through IL-6/IL-11 in cancer-associated fibroblasts promotes colorectal tumour development and correlates with poor prognosis.

Christina KerstenKristina ScheibeAnabel SchmiedCarol I GeppertBenjamin SchmidStefan WirtzOana-Maria ThomaViktoria KramerMaximilian J WaldnerChristian BüttnerHenner F FarinMarina PešićFerdinand KnielingSusanne MerkelAnika GrüneboomMatthias GunzerRobert GrützmannStefan Rose-JohnSergei B KoralovGeorge KolliasMichael ViethArndt HartmannFlorian R GretenMarkus Friedrich NeurathClemens Neufert

Published in: Gut (2019)

Altogether our work demonstrates a critical role of STAT3 activation in CAFs in CRC development.

Keyphrases

poor prognosis
long non coding rna
cell proliferation
extracellular matrix