Involvement of High Mobility Group Box 1 Protein in Optic Nerve Damage in Diabetes.

Published in: Eye and brain (2022)

Thus, diabetes-induced HMGB1 upregulation promotes optic nerve demyelination and inflammation. The regulation of HMGB1 activation has potential to protect optic nerve damage and the abnormalities of visual pathways in diabetic patients.

Keyphrases

optic nerve
oxidative stress
type diabetes
optical coherence tomography
cardiovascular disease
diabetic rats
glycemic control
binding protein
high glucose
transcription factor
poor prognosis
protein protein
drug induced
weight loss
insulin resistance
climate change