Luminal short-chain fatty acids and 5-HT acutely activate myenteric neurons in the mouse proximal colon.
Candice FungBert CoolsSergio MalagolaTobias MartensTack JanYoucef KazwinyPieter Vanden BerghePublished in: Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society (2021)
Taken together, our study demonstrates that different microbial metabolites, including SCFAs and 5-HT, can acutely stimulate Ca2+ signaling in the mucosal epithelium and in enteric neurons.