EphA3 Downregulation by Hypermethylation Associated with Lymph Node Metastasis and TNM Stage in Colorectal Cancer.
Yong WangZhuoqi XuanBaocheng WangDongsheng ZhangChuan ZhangJian-Dong WangYueming SunPublished in: Digestive diseases and sciences (2018)
EphA3 was downregulated in the majority of CRC. Hypermethylation of a CpG island within the EPHA3 promoter provides a possible mechanism. Loss of EphA3 expression was associated with lymph node metastasis and TNM stage and may therefore prove useful as a predictor for tumor spread in CRC.