Spider venom components decrease glioblastoma cell migration and invasion through RhoA-ROCK and Na+/K+-ATPase β2: potential molecular entities to treat invasive brain cancer.
Natália BarretoMarcus CaballeroAmanda Pires BonfantiFelipe Cezar Pinheiro de MatoJaqueline MunhozThomaz A A da Rocha-E-SilvaRafael SuttiJoão Luiz Vitorino-AraujoLiana VerinaudCatarina RapôsoPublished in: Cancer cell international (2020)
All components of the venom were evaluated and two SFs were able to impair human glioblastoma cells. The RhoA effector, ROCK, was shown to be involved in the mechanisms of both PnV components. It is possible that AMOG mediates the effect of SF11 on the invasion. Further investigations to isolate and biochemically characterize the molecules are underway.
Keyphrases
- induced apoptosis
- endothelial cells
- papillary thyroid
- single cell
- cell cycle arrest
- cell therapy
- white matter
- dendritic cells
- squamous cell
- induced pluripotent stem cells
- cell migration
- resting state
- multiple sclerosis
- single molecule
- functional connectivity
- pluripotent stem cells
- mesenchymal stem cells
- climate change
- human health