Cardiovascular risk in ANCA-associated vasculitis: Monocyte phenotyping reveals distinctive signatures between serological subsets.

Yosta VegtingKatie Ml HanfordAldo JongejanGayle Rs GajadinMiranda VerslootNelly D van der Bom-BaylonTamara DekkerE Lars PenneJoost W van der HeijdenEline HoubenFrederike J BemelmanAnnette E NeelePerry D MoerlandLiffert VogtJeffrey KroonMarc L Hilhorst

Published in: Atherosclerosis (2024)

These findings highlight changes in monocyte subset composition and activation, but not in the intrinsic migration capacity of AAV monocytes. MPO-AAV monocytes are associated with sustained upregulation of inflammatory genes, whereas PR3-AAV monocytes exhibit chemokine receptor upregulation. These molecular changes may play a role in elevating cardiovascular risk as well as in the underlying pathophysiology of AAV.

Keyphrases

peripheral blood
dendritic cells
gene therapy
poor prognosis
cell proliferation
genome wide
endothelial cells
oxidative stress
immune response
dna methylation
gene expression
long non coding rna
single molecule
binding protein