Random biopsies in patients harboring a CDH1 mutation: time to change the approach?
Rui CastroJoão LoboInês PitaFlávio VideiraLuís Pedro Fernandes AfonsoMario J Dinis-RibeiroCatarina BrandãoPublished in: Revista espanola de enfermedades digestivas : organo oficial de la Sociedad Espanola de Patologia Digestiva (2021)
gastroscopy has a poor sensitivity to detect SRCC. Even with Cambridge protocol, gastroscopy has a very limited role in the surveillance of patients with a CDH1 mutation and prophylactic total gastrectomy is the most advisable option. Nevertheless, endoscopic protocols should be optimized to favor targeted biopsies over a high number of random biopsies.