Recombinant Treponema pallidum protein Tp0136 promotes fibroblast migration by modulating MCP-1/CCR2 through TLR4.
X LuoZ-X GaoS-W LinM-L TongL-L LiuL-R LinW-J KeTian-Ci YangPublished in: Journal of the European Academy of Dermatology and Venereology : JEADV (2020)
These findings demonstrate that Tp0136 promotes the migration of fibroblasts by inducing MCP-1/CCR2 expression through signalling involving the TLR4, ERK, JNK, PI3K and NF-κB signalling pathways, which could contribute to the mechanism of chancre self-healing in syphilis.
Keyphrases
- signaling pathway
- toll like receptor
- inflammatory response
- pi k akt
- immune response
- dendritic cells
- nuclear factor
- regulatory t cells
- induced apoptosis
- poor prognosis
- lps induced
- binding protein
- human immunodeficiency virus
- cell proliferation
- men who have sex with men
- oxidative stress
- cell death
- extracellular matrix
- hepatitis c virus
- long non coding rna
- cell free
- small molecule