Angiotensin II Receptor Blocker Irbesartan Enhanced SIRT1 longevity Signaling Replaces the Mitochondrial Biogenetic Survival Pathway to Attenuate Hypertension-Induced Heart Apoptosis.
Pei-Ying PaiJames K S WongZhen-Yang CuiYi-Yuan LinShin-Da LeePublished in: Journal of cardiovascular development and disease (2022)
-JNK deactivation, and SIRT1/PGC-1α pro-survival pathway upregulation. ARB prevents hypertension-enhanced cardiac apoptosis via enhancing SIRT1 longevity signaling and enhances the mitochondrial biogenetic survival pathway.
Keyphrases
- oxidative stress
- angiotensin ii
- diabetic rats
- blood pressure
- ischemia reperfusion injury
- angiotensin converting enzyme
- induced apoptosis
- cell death
- endoplasmic reticulum stress
- free survival
- signaling pathway
- cell cycle arrest
- heart failure
- vascular smooth muscle cells
- cell proliferation
- left ventricular
- poor prognosis
- skeletal muscle
- atrial fibrillation
- mouse model
- drug induced
- binding protein
- endothelial cells