Clinical and MRI evolution after local injection of bone marrow-derived mesenchymal stem cells in perianal fistulae in Crohn's disease: results from a prospective monocentric study.
Catherine ReenaersRomain P GillardCarla CoimbraRené M GillardPaul MeunierChantal LechanteurEtienne BaudouxLayla BoutaffalaYves BeguinÉdouard LouisPublished in: Journal of Crohn's & colitis (2023)
Open-label injection of bone marrow-derived mesenchymal stem cells was safe and was effective in half of the patients in fistulizing perianal CD and induced significant MRI changes associated with favorable clinical outcome.
Keyphrases
- bone marrow
- open label
- end stage renal disease
- mesenchymal stem cells
- magnetic resonance imaging
- contrast enhanced
- ejection fraction
- newly diagnosed
- chronic kidney disease
- clinical trial
- diffusion weighted imaging
- peritoneal dialysis
- ultrasound guided
- prognostic factors
- high glucose
- randomized controlled trial
- squamous cell carcinoma
- study protocol
- diabetic rats
- phase ii
- patient reported outcomes
- drug induced
- phase iii