Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons.

Andreas Papassotiropoulos Dominique J-F de Quervain

Published in: Science signaling (2024)

WWC1 is a scaffolding protein in the evolutionarily conserved Hippo signaling network and is genetically linked to human memory and synaptic plasticity. In the archives of Science Signaling , Stepan et al. demonstrate the translational potential of modulating WWC1 through pharmacological inhibition of Hippo-pathway kinases to enhance cognition.

Keyphrases

endothelial cells
working memory
public health
signaling pathway
mild cognitive impairment
white matter
pluripotent stem cells
protein protein
binding protein
human health