The effect of brain serotonin deficit (TPH2-KO) on the expression and activity of liver cytochrome P450 enzymes in aging male Dark Agouti rats.

Anna HaduchEwa BromekWojciech KubanAgnieszka Basińska-ZiobrońPrzemysław J DanekNatalia AleninaMichael BaderWładysława Anna Daniel

Published in: Pharmacological reports : PR (2023)

Rat liver cytochrome P450 functions deteriorate with age, which may impair drug metabolism. The TPH2 knockout, which deprives brain serotonin, affects cytochrome P450 expression and activity differently in mature and senescent male rats.

Keyphrases

poor prognosis
resting state
white matter
binding protein
functional connectivity
cerebral ischemia
long non coding rna
subarachnoid hemorrhage