Malvidin attenuates behavioral and inhibits the TNF-α/Caspase-3/Nrf-2 expression in rotenone-induced Parkinson's disease in rats: insights from molecular docking.

I KazmiF A Al-AbbasiN A R AlmalkiR A SheikhS D Al-QahtaniM S NadeemS BegM Afzal

Published in: European review for medical and pharmacological sciences (2024)

The investigation concludes that malvidin exhibits neuroprotective effects due to its curative effects against inflammation and oxidative stress. These findings suggest that malvidin possesses therapeutic potential against rotenone-triggered behavioral, oxidative, and inflammatory abnormalities in rodents.

Keyphrases

oxidative stress
molecular docking
diabetic rats
induced apoptosis
molecular dynamics simulations
poor prognosis
dna damage
ischemia reperfusion injury
cell death
high glucose
rheumatoid arthritis
rectal cancer
endothelial cells
signaling pathway