Cardiotoxicity Associated with Anti-CD19 Chimeric Antigen Receptor T-Cell (CAR-T) Therapy: Recognition, Risk Factors, and Management.
Ethan A BurnsCesar Giancarlo Gentille SanchezBarry TrachtenbergSai Ravi PingaliKartik AnandPublished in: Diseases (Basel, Switzerland) (2021)
Chimeric antigen receptor T-cells (CAR-T) are improving outcomes in pediatric and adult patients with relapsed or refractory B-cell acute lymphoblastic leukemias and subtypes of non-Hodgkin Lymphoma. As this treatment is being increasingly utilized, a better understanding of the unique toxicities associated with this therapy is warranted. While there is growing knowledge on the diagnosis and treatment of cytokine release syndrome (CRS), relatively little is known about the associated cardiac events that occur with CRS that may result in prolonged length of hospital stay, admission to the intensive care unit for pressor support, or cardiac death. This review focuses on the various manifestations of cardiotoxicity, potential risk factors, real world and clinical trial data on prevalence of reported cardiotoxicity events, and treatment recommendations.
Keyphrases
- risk factors
- clinical trial
- healthcare
- left ventricular
- randomized controlled trial
- acute myeloid leukemia
- stem cells
- liver failure
- heart failure
- combination therapy
- replacement therapy
- clinical practice
- machine learning
- metabolic syndrome
- mesenchymal stem cells
- open label
- risk assessment
- skeletal muscle
- deep learning
- extracorporeal membrane oxygenation
- adverse drug
- hepatitis b virus
- phase ii
- acute respiratory distress syndrome