Integration of Infant Metabolite, Genetic, and Islet Autoimmunity Signatures to Predict Type 1 Diabetes by Age 6 Years.
Bobbie-Jo M Webb-RobertsonErnesto S NakayasuBrigitte I FrohnertLisa M BramerSarah M AkersJill M NorrisKendra VehikAnette-Gabriele ZieglerThomas O MetzStephen S RichMarian J RewersPublished in: The Journal of clinical endocrinology and metabolism (2022)
The metabolite features identified as important for progression to T1D by age 6 years point to altered sugar metabolism in infancy. Integrating this information with classic risk factors improves prediction of the progression to T1D in early childhood.