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Integration of Infant Metabolite, Genetic, and Islet Autoimmunity Signatures to Predict Type 1 Diabetes by Age 6 Years.

Bobbie-Jo M Webb-RobertsonErnesto S NakayasuBrigitte I FrohnertLisa M BramerSarah M AkersJill M NorrisKendra VehikAnette-Gabriele ZieglerThomas O MetzStephen S RichMarian J Rewers
Published in: The Journal of clinical endocrinology and metabolism (2022)
The metabolite features identified as important for progression to T1D by age 6 years point to altered sugar metabolism in infancy. Integrating this information with classic risk factors improves prediction of the progression to T1D in early childhood.
Keyphrases
  • type diabetes
  • risk factors
  • genome wide
  • cardiovascular disease
  • insulin resistance
  • glycemic control
  • weight gain
  • dna methylation
  • metabolic syndrome
  • copy number
  • adipose tissue
  • physical activity
  • weight loss